Antibody Engineering Capabilities
ACGTC’s Antibody Services provide comprehensive support for the development and commercialization of therapeutic and diagnostic antibodies, with a focus on antibody fragments. Recognizing the growing importance of antibodies, which now represent over half of all biopharmaceutical sales, our services are tailored to address the increasing demand for both full-length antibodies and smaller antibody fragments. These fragments, such as Fab, scFv, and VH, are becoming increasingly popular due to their potential for enhanced therapeutic and diagnostic applications.
Protein Engineering
We employ advanced protein engineering techniques, such as linker design, protein fusions, and conjugates, to create next-generation antibody fragments with improved functionality.
Antibody Production
Our production capabilities include microbial (E. coli, P. pastoris) and mammalian (CHO, HEK) systems, with the capacity to scale up to 5-liter fermenters or bioreactors for recombinant antibody or protein production.
Antibody Discovery
Using technologies like phage display and yeast surface display, we discover antibodies for novel targets, enhancing the therapeutic potential of our projects.
Characterization and Purification
Technology Transfer
We facilitate the transfer of our antibody and protein technologies to industry partners, ensuring seamless integration into commercial pipelines.
We provide extensive characterization services using HPLC, UPLC, Mass Spec, SDS-PAGE, Western Blot, Surface Plasmon Resonance, ELISA, and thermal melt analysis. Our purification processes utilize FPLC to ensure the highest purity of antibodies and proteins.
Antibody Fragment Development
We specialize in developing various antibody fragment formats, including Fab, scFv, and VH, from full-length antibodies. These fragments are thoroughly tested and characterized for their therapeutic and diagnostic potential.
Antibody Discovery
Using technologies like phage display and yeast surface display, we discover antibodies for novel targets, enhancing the therapeutic potential of our projects.
Antibody Production
Our production capabilities include microbial (E. coli, P. pastoris) and mammalian (CHO, HEK) systems, with the capacity to scale up to 5-liter fermenters or bioreactors for recombinant antibody or protein production.
Characterization and Purification
We provide extensive characterization services using HPLC, UPLC, Mass Spec, SDS-PAGE, Western Blot, Surface Plasmon Resonance, ELISA, and thermal melt analysis. Our purification processes utilize FPLC to ensure the highest purity of antibodies and proteins.
Antibody Fragment Development
We specialize in developing various antibody fragment formats, including Fab, scFv, and VH, from full-length antibodies. These fragments are thoroughly tested and characterized for their therapeutic and diagnostic potential.
Protein Engineering
We employ advanced protein engineering techniques, such as linker design, protein fusions, and conjugates, to create next-generation antibody fragments with improved functionality.
Technology Transfer
We facilitate the transfer of our antibody and protein technologies to industry partners, ensuring seamless integration into commercial pipelines.
ACGTC’s Antibody Services provide comprehensive support for the development and commercialization of therapeutic and diagnostic antibodies, with a focus on antibody fragments. Recognizing the growing importance of antibodies, which now represent over half of all biopharmaceutical sales, our services are tailored to address the increasing demand for both full-length antibodies and smaller antibody fragments. These fragments, such as Fab, scFv, and VH, are becoming increasingly popular due to their potential for enhanced therapeutic and diagnostic applications.